Salmon injections (PDRN) increase collagen production in large quantities in the skin, which leads to:
• Results begin to appear from the first session, but since the treatment is based on the stimulation of natural collagen in the skin, the results appear gradually during the treatment period. The best results usually begin to appear after 3 to 4 sessions.
It is important to note that results vary from person to person, depending on the rate of cell renewal in each individual. However, most reviewers notice skin improvement several days after the first session.
• Yes, salmon injections can be used as a complementary measure to many cosmetic techniques to enhance and accelerate the appearance of results.
• It can be combined with skin tightening techniques such as Althera, Thermage Flex, or Attiva skin tightening technique.
• Can be safely used in combination with other cosmetic techniques such as microneedling, fractional and fraxel to treat scars.
• The appropriate treatment program is determined based on the expected results of the treatment by the doctor.
• Salmon needle for face is a type of cosmetic injection that is extracted from the DNA of salmon fish.
• This needle contains biological molecules known as riboxic acid (PDRN), which has regenerative properties, as it helps stimulate collagen production, reduces signs of aging on the skin, and treats scars by promoting cell growth and repairing damaged tissue.
For best results, doctors make some recommendations after the injection, including:
• Do not use cosmetics within the first 24 hours.
• Avoid direct exposure to the sun, and use SPF 30+ sunscreen when needed.
• Stop using home scrubs, and use gentle and unscented skin moisturizers.
• After the end of the treatment program, it is recommended to do one session every 6-12 months to maintain the results.
• Avoid strenuous sports activities for 48 hours, and avoid high heat such as saunas and jacuzzis.
Nucleotides or polynucleotides (PDRNs) are biopolymers, as is hyaluronic acid. They consist of links of two different nucleic acids, DNA and RNA, which are extracted from the milk of trout, salmon, or sturgeon fish. Why fish? The DNA structure of the milk of these fish species is as similar as possible to the DNA of human leukocytes. And for humans, their use is completely safe.
One of the mechanisms of skin aging is the accumulation of various damages in the structure of DNA and RNA molecules of the cell. So-called “breakdowns” begin in their molecules, which trigger the mechanisms of cell death. And from that moment on, aging begins. The effect of polynucleotides in special preparations is that they restore existing damage by replacing broken nucleotides in DNA and RNA. Their main function is to recognize and repair damage.
There is absolutely no reason to be worried. Molecules in PDRN products for aesthetic medicine are negligible (50–20,000 pairs of nucleotides) compared to the several million pairs of nucleotides that form genes. Therefore, they are not able to transfer and modify genetic information. In this case, polynucleotides work as a kind of “repair agent"—they" restore only damaged nucleotides. Thus, we can talk about the safety of products based on PDRN.
Possessing an immunomodulatory effect, polynucleotides stimulate the processes of regeneration and repair and enhance the synthesis of elastin, collagen, and non-collagen molecules. Promotes optimal hydration as well as protection against UVA and UVB. Which in turn leads to a general improvement in skin condition, rejuvenation, and lifting effect. At the same time, polynucleotides are able to adsorb and neutralize free radicals, cleansing the skin of toxins. The indisputable advantage of polynucleotides is the ability to stimulate physiological processes, rejuvenating not only the appearance but the entire body. Smart acids provoke the growth of young functional structures and do not squeeze out the last forces from the existing ones, which can no longer provide the skin with hyaluronic acid.
PDRN provides deep skin hydration, smoothing of fine lines and wrinkles, boosting of collagen and elastin levels, and dermal remodeling over time. Your complexion will appear healthy, hydrated, and glowing with improved elasticity.
PDRN molecules are able to stimulate the metabolic activity of cells in your skin to regenerate collagen. It can also stimulate wound recovery by boosting the rate of growth of fibroblasts, the cells mainly responsible for collagen production. PDRN treatment has primary effects:
It is recommended to have 3-4 treatments every 2–4 weeks. Your doctor will be able to best recommend the frequency of treatments according to your skin condition, area, and injectable.
PDRN therapy is a long-lasting treatment upon consistent treatment sessions. Results can be seen from the first session, and long-lasting biostimulation effects are achieved after the initial phase of 2-3 sessions at 1 month apart.
The main ingredient in biorevitalization is pure concentrated hyaluronic acid, while PDRN injections are a biostimulant gel made from polynucleotides.
Hyaluronic acid (HA) is a naturally occurring compound found in skin, muscle, and joints. The ability of HA to readily bind to water molecules and HA being able to draw up to 1000 times its weight in water makes biorevitalization ideal for providing excellent hydration to the skin. The high concentration of pure HA in biorevitalization is also able to encourage bio-remodeling by inducing the body’s natural healing response to increase collagen and elastin by stimulating fibroblast cells, improving the skin’s structure, elasticity, and firmness, and giving the skin a plump and dewy look.
While PDRN are also able to bind to water to provide deep hydration to the skin, they do not draw in as much water as biorevitalization. Thus, PDRN may be more suitable for areas of the face with thinner skin where excessive water retention is undesirable.
Unlike biorevitalization, PDRN therapy is a biostimulant capable of activating fibroblast cells into type I collagen and elastin-producing myofibroblasts by directly stimulating specific receptors on the fibroblast cells, achieving bioregeneration and rejuvenation of the skin due to the sustained and increased production of collagen by myofibroblasts. Results for PDRN therapy also typically last longer than biorevitalization.
In summary, these two treatments are compatible with each other and can be combined for better results.
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